Article
Single Cell Analysis Of Transcriptionally Active Alleles By Single Molecule FISH.
Journal of visualized experiments : JoVE - 20 Sept 2020
Mistry Ragini M, Singh Pankaj K, Mancini Maureen G, Stossi Fabio, Mancini Michael A
Abstract excerpt
Gene transcription is an essential process in cell biology, and allows cells to interpret and respond to internal and external cues. Traditional bulk population methods (Northern blot, PCR, and RNAseq) that measure mRNA levels lack the ability to provide information on cell-to-cell variation in responses. Precise single cell and allelic visualization and quantification is possible via single molecule RNA...
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