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Analysis across multiple tumor types provides no evidence that mutant p53 exerts dominant negative activity

27 Dec 2018

Abstract excerpt

Abstract Missense mutations in the TP53-binding domain predominate, and >30% of these occur in just eight codons. Dominant negative properties of mutant p53, taken together with the mutation susceptibility of the nucleotides in the codon, are believed to explain the prevalence of specific mutations, including hot spots. We analyzed multiple tumor types and found no difference in clinical characteristics or...

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PMID: 30623031
DOI: 10.1038/s41698-018-0074-x

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