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Senescent glia link mitochondrial dysfunction and lipid accumulation

5 Jun 2024

Abstract excerpt

Abstract Senescence is a cellular state linked to ageing and age-onset disease across many mammalian species 1,2 . Acutely, senescent cells promote wound healing 3,4 and prevent tumour formation 5 ; but they are also pro-inflammatory, thus chronically exacerbate tissue decline. Whereas senescent cells are active targets for anti-ageing therapy 6–11 , why these cells form in vivo, how they affect tissue ageing and...

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PMID: 38839958
DOI: 10.1038/s41586-024-07516-8

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