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Article

EAP1 regulation of GnRH promoter activity is important for human pubertal timing

2 Jan 2019

Abstract excerpt

The initiation of puberty is orchestrated by an augmentation of gonadotropin-releasing hormone (GnRH) secretion from a few thousand hypothalamic neurons. Recent findings have indicated that the neuroendocrine control of puberty may be regulated by a hierarchically organized network of transcriptional factors acting upstream of GnRH. These include enhanced at puberty 1 (EAP1), which contributes to the initiation...

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PMID: 30608578
DOI: 10.1093/hmg/ddy451

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