Article

Variation in the Timing of Puberty: Clinical Spectrum and Genetic Investigation

2001-06-01

Abstract excerpt

Human puberty begins with the reemergence of GnRH secretion from its relative quiescence during childhood, activating a cascade of pituitary-gonadal maturation. This transition begins across a wide range of ages, and the rate of subsequent sexual maturation can be quite varied. The factors that regulate the hypothalamic-pituitary-gonadal axis and modulate the timing of puberty remain elusive, but it is clear that...

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Literature Corpus work: 4773fd73-e7c9-51f9-81e8-e46a59e159a3
DOI: 10.1210/jc.86.6.2364

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