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Article

Large Genomic Aberrations in Corticotropinomas Are Associated With Greater Aggressiveness

28 Dec 2018

Abstract excerpt

CONTEXT: Genomic losses/gains are associated with cancer progression and prognosis. In pituitary adenomas, analyses of copy number variations (CNVs) have shown that a subset of adenomas have higher genomic variability. However, whether CNVs are associated with tumor aggressiveness and prognosis has not been determined. OBJECTIVE: We hypothesized that somatic CNVs of pituitary tumors may play a role in the...

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PMID: 30597087
DOI: 10.1210/jc.2018-02164

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