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Article

Asymmetric Distribution of Primary Cilia Allocates Satellite Cells for Self-Renewal

5 May 2016

Abstract excerpt

Regeneration of vertebrate skeletal muscles requires satellite cells, a population of stem cells that are quiescent in normal conditions and divide, differentiate, and self-renew upon activation triggered by exercise, injury, and degenerative diseases. Satellite cell self-renewal is essential for long-term tissue homeostasis, and previous work has identified a number of external cues that control this process....

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PMID: 27161363
DOI: 10.1016/j.stemcr.2016.04.004

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