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Article

Down-regulation of Aurora B kinase induces cellular senescence in human fibroblasts and endothelial cells through a p53-dependent pathway.

FEBS letters - 16 Nov 2011

Kim Hee-Jin, Cho Jung Hee, Quan Hexiu, Kim Jae-Ryong

Abstract excerpt

Aurora B kinase (Aurora-B) functions in chromosome segregation and cleavage of polar spindle microtubules. However, its role in cellular senescence remains elusive. Here, we investigated Aurora-B effects on cellular senescence in human fibroblasts and endothelial cells. Aurora-B levels were reduced during replicative senescence and premature senescence by adriamycin. Aurora-B overexpression in old cells partially...

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Identifiers

PMID: 22024481
DOI: 10.1016/j.febslet.2011.10.022

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