Article
Ndel1 suppresses ciliogenesis in proliferating cells by regulating the trichoplein-Aurora A pathway.
The Journal of cell biology - 15 Feb 2016
Inaba Hironori, Goto Hidemasa, Kasahara Kousuke, Kumamoto Kanako, Yonemura Shigenobu, Inoko Akihito, Yamano Shotaro, Wanibuchi Hideki, He Dongwei, Goshima Naoki, Kiyono Tohru, Hirotsune Shinji, Inagaki Masaki
Abstract excerpt
Primary cilia protrude from the surface of quiescent cells and disassemble at cell cycle reentry. We previously showed that ciliary reassembly is suppressed by trichoplein-mediated Aurora A activation pathway in growing cells. Here, we report that Ndel1, a well-known modulator of dynein activity, localizes at the subdistal appendage of the mother centriole, which nucleates a primary cilium. In the presence of...
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