Article

Growth Factor-Independent mTORC1 Signaling Promotes Primary Cilia Length via Suppression of Autophagy

2025-05-07

Abstract excerpt

<h4>ABSTRACT/SUMMARY</h4> The mechanistic target of rapamycin (mTOR) complex 1 (mTORC1), as a sensor of growth signals that subsequently controls cell growth, has been predominantly studied in actively proliferating cells. Primary cilia are sensory organelles present on most quiescent cells, where they play essential roles in receiving environmental and developmental signals. Given that ciliated cells are non-pro...

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Literature Corpus work: 879db4de-02b5-5d64-930b-0eb6cd5fb0de
DOI: 10.1101/2025.05.07.652626

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