Clinical and Laboratory Characteristics of Pediatric Patients With ACKR1/DARC-Associated Neutropenia.

doi:10.1002/pbc.31430

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Clinical and Laboratory Characteristics of Pediatric Patients With ACKR1/DARC-Associated Neutropenia.

Pediatric blood & cancer - 1 Jan 2025

Oz-Alcalay Lital, Steinberg-Shemer Orna, Elron Eyal, Dvori Michal, Elitzur Sarah, Dgany Orly, Noy-Lotan Sharon, Krasnov Tanya, Tamary Hannah, Brik-Simon Dafna, Yacobovich Joanne, Gilad Oded

Abstract excerpt

BACKGROUND: ACKR1/DARC-associated neutropenia (ADAN), resulting from homozygosity for a single nucleotide polymorphism (SNP) in the ACKR1/DARC gene (rs2814778), is a common cause of benign neutropenia that primarily affects individuals of African and Jewish Yemenite descent. We aimed to characterize ADAN in pediatric patients in Israel, given its ethnically diverse population. PROCEDURE: We assessed children with...

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PMID: 39506297
DOI: 10.1002/pbc.31430

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