Factor IX Amagasaki: a new mutation in the catalytic domain resulting in the loss of both coagulant and esterase activities.

doi:10.1021/bi00111a014

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Article

Factor IX Amagasaki: a new mutation in the catalytic domain resulting in the loss of both coagulant and esterase activities.

Biochemistry - 26 Nov 1991

Miyata T, Sakai T, Sugimoto M, Naka H, Yamamoto K, Yoshioka A, Fukui H, Mitsui K, Kamiya K, Umeyama H

Abstract excerpt

Factor IX Amagasaki (AMG) is a naturally occurring mutant of factor IX having essentially no coagulant activity, even though normal levels of antigen are detected in plasma. Factor IX AMG was purified from the patient's plasma by immunoaffinity chromatography with an anti-factor IX monoclonal antibody column. Factor IX AMG was cleaved normally by factor VIIa-tissue factor complex, yielding a two-chain factor IXa....

Topics

Amino Acid Sequence
Animals
Base Sequence
Blood Coagulation
Cattle
DNA
Exons
Factor IXa
Factor VIII
Factor X
Hemophilia A
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Models, Molecular

Molecular Sequence Data

Mutation

Oligodeoxyribonucleotides

Polymerase Chain Reaction

Source

Open in PubMed

Identifiers

PMID: 1958666
DOI: 10.1021/bi00111a014

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1958666-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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