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Article

Inactivation of human coagulation factor X by a protease of the pathogen Capnocytophaga canimorsus.

Journal of thrombosis and haemostasis : JTH - 1 Mar 2017

Hack K, Renzi F, Hess E, Lauber F, Douxfils J, Dogné J M, Cornelis G R

Abstract excerpt

Essentials Capnocytophaga canimorsus causes severe dog bite related blood stream infections. We investigated if C. canimorsus contributes to bleeding abnormalities during infection. The C. canimorsus protease CcDPP7 causes factor X dysfunction by N-terminal cleavage. CcDPP7 inhibits coagulation in vivo, which could promote immune evasion and trigger hemorrhage. SUMMARY: Background Capnocytophaga canimorsus is a...

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Identifiers

PMID: 28029716
DOI: 10.1111/jth.13605

Genes

DPP7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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