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Article

Phosphorylation of FADD by the kinase CK1α promotes KRASG12D-induced lung cancer.

Science signaling - 27 Jan 2015

Bowman Brittany M, Sebolt Katrina A, Hoff Benjamin A, Boes Jennifer L, Daniels Danette L, Heist Kevin A, Galbán Craig J, Patel Rajiv M, Zhang Jianke, Beer David G, Ross Brian D, Rehemtulla Alnawaz, Galbán Stefanie

Abstract excerpt

Genomic amplification of the gene encoding and phosphorylation of the protein FADD (Fas-associated death domain) is associated with poor clinical outcome in lung cancer and in head and neck cancer. Activating mutations in the guanosine triphosphatase RAS promotes cell proliferation in various cancers. Increased abundance of phosphorylated FADD in patient-derived tumor samples predicts poor clinical outcome. Using...

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Source

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Identifiers

PMID: 25628462
DOI: 10.1126/scisignal.2005607
PMCID: PMC4416214

Genes

FADD
KRAS
AURKA
BUB1
PLK1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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