Clinicopathologic characteristics, co-mutation landscape, and survival outcomes of KRAS-G12D mutant lung adenocarcinoma in comparison to KRAS-G12C and EGFR-mutated subtypes.

doi:10.1016/j.lungcan.2025.108596

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Article

Clinicopathologic characteristics, co-mutation landscape, and survival outcomes of KRAS-G12D mutant lung adenocarcinoma in comparison to KRAS-G12C and EGFR-mutated subtypes.

Lung cancer (Amsterdam, Netherlands) - 1 Jul 2025

Abolfathi Hanie, Kordahi Manal, Armero Victoria Saavedra, Gagné Andréanne, Desmeules Patrice, Orain Michèle, Fiset Pierre Oliver, Boudreau Dominique K, Gaudreault Nathalie, Lamaze Fabien Claude, Bossé Yohan, Joubert Philippe

Abstract excerpt

Given the ongoing clinical development of KRASG12D specific inhibitors, we aimed to explore the clinicopathologic characteristics of KRASG12D mutant tumors. We analyzed 1,225 surgically resected LUAD from a large cohort of a French-Canadian cohort. Tumors were classified into five mutually exclusive molecular groups: KRASG12D (n = 82), KRASG12C (n = 311), KRASnon-G12C/G12D (n = 324), EGFR-mutant (n = 175), and WT...

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Topics

Humans
Male
ErbB Receptors
Female
Proto-Oncogene Proteins p21(ras)

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Mutation

Middle Aged

Lung Neoplasms

Aged

Adenocarcinoma of Lung

Prognosis

Aged, 80 and over

Adult

Neoplasm Staging

Adenocarcinoma

Source

Open in PubMed

Identifiers

PMID: 40441025
DOI: 10.1016/j.lungcan.2025.108596

Genes

EGFR
KRAS
BRAF
GNAS
TP53

Variants

Provenance

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