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A multiomic approach to characterize the temporal sequence in Alzheimer's disease-related pathology

15 Dec 2018

Abstract excerpt

No single-omic approach completely elucidates the multitude of alterations taking place in Alzheimer's disease (AD). Here, we coupled transcriptomic and phosphoproteomic approaches to determine the temporal sequence of changes in mRNA, protein, and phosphopeptide expression levels from human temporal cortical samples, with varying degree of AD-related pathology. This approach highlighted fluctuation in synaptic...

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PMID: 30557660
DOI: 10.1016/j.nbd.2018.12.009

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