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Article

Overexpression of snail induces epithelial-mesenchymal transition and a cancer stem cell-like phenotype in human colorectal cancer cells.

Cancer medicine - 1 Aug 2012

Fan Fan, Samuel Shaija, Evans Kurt W, Lu Jia, Xia Ling, Zhou Yunfei, Sceusi Eric, Tozzi Federico, Ye Xiang-Cang, Mani Sendurai A, Ellis Lee M

Abstract excerpt

Epithelial-mesenchymal transition (EMT) is a critical process providing tumor cells with the ability to migrate and escape from the primary tumor and metastasize to distant sites. Recently, EMT was shown to be associated with the cancer stem cell (CSC) phenotype in breast cancer. Snail is a transcription factor that mediates EMT in a number of tumor types, including colorectal cancer (CRC). Our study was done to...

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Identifiers

PMID: 23342249
DOI: 10.1002/cam4.4
PMCID: PMC3544430

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