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DNA damage and repair in human oocytes and embryos: a review

21 Jul 2010

Abstract excerpt

The genome of all cells is protected at all times by mechanisms collectively known as DNA repair activity (DRA). Such activity is particularly important at the beginning of human life, i.e. at fertilization, immediately after and at the very onset of embryonic development. DRA in early development is, by definition, of maternal origin: the transcripts stored during maturation, need to control the integrity of...

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PMID: 20663262
DOI: 10.1017/s0967199410000286

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