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Article

Analysis of whole genome sequence data shows association of Alzheimer's disease with rare coding variants in ABCA7, PSEN1, SORL1 and TREM2.

Journal of neurogenetics - 1 Dec 2025

Curtis David, Joseph Shujaani

Abstract excerpt

Previous studies have reported associations between risk of Alzheimer's disease (AD) or dementia and rare coding variants in a number of genes. A two-stage strategy was used in which a previously released whole exome sequenced sample was used to prioritise 100 genes showing the strongest evidence for association with AD. These genes were then analysed in a newly released whole genome sequenced sample to identify...

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Source

Identifiers

PMID: 40990081
DOI: 10.1080/01677063.2025.2561589

Genes

ABCA7
PSEN1
SORL1
TREM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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Analysis of whole genome sequence data shows association of Alzheimer's disease with rare coding variants in ABCA7, PSEN1, SORL1 and TREM2.PMID 40990081Read ↗

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