Article

Missense and Loss of Function Variants at GWAS Loci in Familial Alzheimer’s Disease

2023-12-18

Abstract excerpt

<h4>BACKGROUND</h4> Few rare variants have been identified in genetic loci from genome wide association studies of Alzheimer’s disease (AD), limiting understanding of mechanisms and risk assessment, and genetic counseling. <h4>METHODS</h4> Using genome sequencing data from 197 families in The NIA Alzheimer’s Disease Family Based Study, and 214 Caribbean Hispanic families, we searched for rare coding variants withi...

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Literature Corpus work: 799a46c0-e120-5dfe-9af7-183bbd743548
DOI: 10.1101/2023.12.18.23300145

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