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Article

P53 mutations in colorectal cancer - molecular pathogenesis and pharmacological reactivation.

World journal of gastroenterology - 7 Jan 2015

Li Xiao-Lan, Zhou Jianbiao, Chen Zhi-Rong, Chng Wee-Joo

Abstract excerpt

Colorectal cancer (CRC) is one of the most common malignancies with high prevalence and low 5-year survival. CRC is a heterogeneous disease with a complex, genetic and biochemical background. It is now generally accepted that a few important intracellular signaling pathways, including Wnt/β-catenin signaling, Ras signaling, and p53 signaling are frequently dysregulated in CRC. Patients with mutant p53 gene are...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25574081
DOI: 10.3748/wjg.v21.i1.84
PMCID: PMC4284363

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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