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Article

Application of an <i>ex vivo</i> cellular model of circadian variation for bipolar disorder research: a proof of concept study

20 Jun 2013

Abstract excerpt

OBJECTIVES: Disruption of circadian function has been observed in several human disorders, including bipolar disorder (BD). Research into these disorders can be facilitated by human cellular models that evaluate external factors (zeitgebers) that impact circadian pacemaker activity. Incorporating a firefly luciferase reporter system into human fibroblasts provides a facile, bioluminescent readout that estimates...

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PMID: 23782472
DOI: 10.1111/bdi.12095

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