Article
HDAC8 overexpression in mesenchymal stromal cells from JAK2+ myeloproliferative neoplasms: a new therapeutic target?
Oncotarget - 25 Apr 2017
Ramos Teresa L, Sánchez-Abarca Luis Ignacio, Redondo Alba, Hernández-Hernández Ángel, Almeida Antonio M, Puig Noemí, Rodríguez Concepción, Ortega Rebeca, Preciado Silvia, Rico Ana, Muntión Sandra, Porras José Ramón González, Del Cañizo Consuelo, Sánchez-Guijo Fermín
Abstract excerpt
Histone deacetylases (HDACs) are involved in epigenetic modulation and their aberrant expression has been demonstrated in myeloproliferative neoplasms (MPN). HDAC8 inhibition has been shown to inhibit JAK2/STAT5 signaling in hematopoietic cells from MPN. Nevertheless, the role of HDAC8 expression in bone marrow-mesenchymal stromal cells (BM-MSC) has not been assessed. In the current work we describe that HDAC8 is...
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