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Development of an oligonucleotide microarray for simultaneous detection of two canine MDR1 genotypes and association between genotypes and chemotherapy side effects

1 Jan 2019

Abstract excerpt

Canine MDR1 gene mutations produce translated P-glycoprotein, an active drug efflux transporter, resulting in dysfunction or over-expression. The 4-base deletion at exon 4 of MDR1 at nucleotide position 230 (nt230[del4]) in exon 4 makes P-glycoprotein lose function, leading to drug accumulation and toxicity. The G allele of the c.-6-180TG variation in intron 1 of MDR1 (single nucleotide polymorphism [SNP] 180)...

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PMID: 30481983
DOI: 10.4142/jvs.2019.20.1.27

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