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Article

Mutations in the intersubunit bridge regions of 16S rRNA affect decoding and subunit-subunit interactions on the 70S ribosome.

Nucleic acids research - 1 Apr 2011

Sun Qing, Vila-Sanjurjo Antón, O'Connor Michael

Abstract excerpt

The small and large subunits of the ribosome are held together by a series of bridges, involving RNA-RNA, RNA-protein and protein-protein interactions. Some 12 bridges have been described for the Escherichia coli 70S ribosome. In this work, we have targeted for mutagenesis, some of the 16S rRNA residues involved in the formation of intersubunit bridges B3, B5, B6, B7b and B8. In addition to effects on subunit...

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Identifiers

PMID: 21138965
DOI: 10.1093/nar/gkq1253
PMCID: PMC3082907

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