Article
[Molecular basis of Huntington's disease and possible pathogenic mechanisms].
Revista de neurologia - 1 Jan 2000
Martín Aparicio E, Lucas J J
Abstract excerpt
INTRODUCTION: Huntington s disease is one of the, at least, nine neurological disorders caused by a CAG triplet expansion coding for a poly glutamine sequence in the corresponding protein. Huntington s disease affects 3 7 in 100.000 individuals in Western Europe descendent population and the symptomatology comprises motor (including chorea and rigidity), cognitive (subcortical dementia), and psychological...
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