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Article

Hyperexcitable interneurons trigger cortical spreading depression in an Scn1a migraine model.

The Journal of clinical investigation - 1 Nov 2021

Auffenberg Eva, Hedrich Ulrike Bs, Barbieri Raffaella, Miely Daniela, Groschup Bernhard, Wuttke Thomas V, Vogel Niklas, Lührs Philipp, Zanardi Ilaria, Bertelli Sara, Spielmann Nadine, Gailus-Durner Valerie, Fuchs Helmut, Hrabě de Angelis Martin, Pusch Michael, Dichgans Martin, Lerche Holger, Gavazzo Paola, Plesnila Nikolaus, Freilinger Tobias

Abstract excerpt

Cortical spreading depression (CSD), a wave of depolarization followed by depression of cortical activity, is a pathophysiological process implicated in migraine with aura and various other brain pathologies, such as ischemic stroke and traumatic brain injury. To gain insight into the pathophysiology of CSD, we generated a mouse model for a severe monogenic subtype of migraine with aura, familial hemiplegic...

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Identifiers

PMID: 34546973
DOI: 10.1172/JCI142202
PMCID: PMC8553559

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