Hemiplegic migraine: genetics and pathophysiology.

Abstract excerpt

Rare monogenic subtypes of migraine with aura, which include an autosomal dominant form of hemiplegic migraine (HM), are caused by exonic mutations whose functional consequences can be studied in cellular and animal models of the disease. This allows investigation of the neurobiological mechanisms at the molecular, cellular, and circuit level. Here, I review current knowledge of the genetics and pathophysiology...

Topics

• Animals
• Humans
• Migraine with Aura
• Mice
• Disease Models, Animal
• Mutation
• Cortical Spreading Depression