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Article

Estimating the contribution of CD4 T cell subset proliferation and differentiation to HIV persistence

2 Oct 2023

Abstract excerpt

Abstract Persistence of HIV in people living with HIV (PWH) on suppressive antiretroviral therapy (ART) has been linked to physiological mechanisms of CD4+ T cells. Here, in the same 37 male PWH on ART we measure longitudinal kinetics of HIV DNA and cell turnover rates in five CD4 cell subsets: naïve (T N ), stem-cell- (T SCM ), central- (T CM ), transitional- (T TM ), and effector-memory (T EM ). HIV decreases...

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PMID: 37783718
DOI: 10.1038/s41467-023-41521-1

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