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Article

Conserved regulation of Nodal-mediated left-right patterning in zebrafish and mouse.

Development (Cambridge, England) - 10 Dec 2018

Montague Tessa G, Gagnon James A, Schier Alexander F

Abstract excerpt

Nodal is the major effector of left-right axis development. In mice, Nodal forms heterodimers with Gdf1 and is inhibited by Cerl2/Dand5 at the node, and by Lefty1 in the lateral plate mesoderm (LPM). Studies in zebrafish have suggested some parallels, but also differences, between left-right patterning in mouse and zebrafish. To address these discrepancies, we generated single and double zebrafish mutants for...

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Identifiers

PMID: 30446628
DOI: 10.1242/dev.171090
PMCID: PMC6307886

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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