Article
Genome-wide association reveals contribution of MRAS to painful temporomandibular disorder in males.
Pain - 1 Mar 2019
Smith Shad B, Parisien Marc, Bair Eric, Belfer Inna, Chabot-Doré Anne-Julie, Gris Pavel, Khoury Samar, Tansley Shannon, Torosyan Yelizaveta, Zaykin Dmitri V, Bernhardt Olaf, de Oliveira Serrano Priscila, Gracely Richard H, Jain Deepti, Järvelin Marjo-Riitta, Kaste Linda M, Kerr Kathleen F, Kocher Thomas, Lähdesmäki Raija, Laniado Nadia, Laurie Cathy C, Laurie Cecelia A, Männikkö Minna, Meloto Carolina B, Nackley Andrea G, Nelson Sarah C, Pesonen Paula, Ribeiro-Dasilva Margarete C, Rizzatti-Barbosa Celia M, Sanders Anne E, Schwahn Christian, Sipilä Kirsi, Sofer Tamar, Teumer Alexander, Mogil Jeffrey S, Fillingim Roger B, Greenspan Joel D, Ohrbach Richard, Slade Gary D, Maixner William, Diatchenko Luda
Abstract excerpt
Painful temporomandibular disorders (TMDs) are the leading cause of chronic orofacial pain, but its underlying molecular mechanisms remain obscure. Although many environmental factors have been associated with higher risk of developing painful TMD, family and twin studies support a heritable genetic component as well. We performed a genome-wide association study assuming an additive genetic model of TMD in a...
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