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Genome-wide association study identifies novel genetic variants associated with widespread pain in the UK Biobank (N = 172,230).

Molecular pain - 1 Jan 2025

Pan Qi, Cai Tengda, Tao Yiwen, Yang Luning, Compte Roger, Naeini Maryam Kazemi, Haque Mainul, Dottorini Tania, Williams Frances Mk, Meng Weihua

Abstract excerpt

OBJECTIVES: Widespread pain is a hallmark characteristic of fibromyalgia, commonly affecting older individuals. This study aimed to identify novel genetic variants associated with widespread pain by utilizing the extensive UK Biobank dataset. METHODS: We conducted a primary genome-wide association study (GWAS) using a novel definition of widespread pain, defined as pain experienced all over the body during the...

Topics

Humans
Genome-Wide Association Study
Male
Female
United Kingdom
Biological Specimen Banks
Genetic Predisposition to Disease
Polymorphism, Single Nucleotide
Middle Aged
Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Variation

Pain

UK Biobank

Source

Open in PubMed Open full text

Identifiers

PMID: 40509746
DOI: 10.1177/17448069251346603
PMCID: PMC12166267

Genes

ARHGEF28
LRMDA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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