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Article

Methylation Quantitative Trait Locus Analysis of Chronic Postsurgical Pain Uncovers Epigenetic Mediators of Genetic Risk

1 Apr 2021

Abstract excerpt

Background: Overlap of pathways enriched by single nucleotide polymorphisms and DNA-methylation underlying chronic postsurgical pain (CPSP), prompted pilot study of CPSP-associated methylation quantitative trait loci (meQTL). Materials & methods: Children undergoing spine-fusion were recruited prospectively. Logistic-regression for genome- and epigenome-wide CPSP association and DNA-methylation-single nucleotide...

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PMID: 33820434
DOI: 10.2217/epi-2020-0424

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