Article
Cyclin D1 splice variant and risk for non-Hodgkin lymphoma.
Human genetics - 1 Sept 2006
Wang Sophia S, Cozen Wendy, Severson Richard K, Hartge Patricia, Cerhan James R, Davis Scott, Welch Robert, Rothman Nathaniel, Chanock Stephen J
Abstract excerpt
To investigate the role of cell cycle gene variations in lymphomagenesis, we evaluated associations (odds ratios [OR] and 95% confidence intervals [CI]) in polymorphisms from seven candidate genes in 1,172 non-Hodgkin lymphoma (NHL) cases and 982 population-based controls. The cyclin D1 (CCND1) splice variant G870A (rs603965) increased NHL risk (OR(AA) = 1.4, 95% CI = 1.1-1.8, P-trend = 0.021), which was...
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