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Single senescent cell sequencing reveals heterogeneity in senescent cells induced by telomere erosion

12 Nov 2018

Abstract excerpt

Dear Editor, Over a half-century ago, Dr. Leonard Hayflick described the phenotype of a finite lifespan for human fibroblasts being passaged in in vitro cell culture (Hayflick et al., 1961), a phenomenon today known as replicative cellular senescence. Cellular senescence has been defined as a state in which cells lose their potential to divide and are permanently arrested in either the G1, or arguably the G2...

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PMID: 30421359
DOI: 10.1007/s13238-018-0591-y

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