Article

Can circulating tumor DNA be used for direct and early stage cancer detection?

2017-12-13

Abstract excerpt

In the August 16th issue of Science Translational Medicine, Phallen et al propose a method for early cancer diagnosis by using circulating tumor DNA (1). One major advance of this paper includes optimized sequencing of cell-free/circulating tumor DNA (ctDNA) without knowledge of tumor mutations. Evaluation of 200 patients with colorectal, breast, lung and ovarian cancer revealed mutations in ctDNA in approx. 60-70...

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Literature Corpus work: 3b408eaa-066b-5054-9f9b-f9d4657995db
DOI: 10.12688/f1000research.13440.1

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