Article

Selecting short DNA fragments in plasma improves detection of circulating tumour DNA

2017-05-05

Abstract excerpt

<h4>Introductory paragraph</h4> Non-invasive analysis of cancer genomes using cell-free circulating tumour DNA (ctDNA) is being widely implemented for clinical indications. The sensitivity for detecting the presence of ctDNA and genomic changes in ctDNA is limited by its low concentration compared to cell-free DNA of non-tumour origin. We studied the feasibility for enrichment of ctDNA by size selection, in plasm...

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Literature Corpus work: 2938c31e-8316-5b37-afa9-f82f9b021a03
DOI: 10.1101/134437

Open publication

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