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Article

PRC2 loss induces chemoresistance by repressing apoptosis in T cell acute lymphoblastic leukemia

7 Nov 2018

Abstract excerpt

The tendency of mitochondria to undergo or resist BCL2-controlled apoptosis (so-called mitochondrial priming) is a powerful predictor of response to cytotoxic chemotherapy. Fully exploiting this finding will require unraveling the molecular genetics underlying phenotypic variability in mitochondrial priming. Here, we report that mitochondrial apoptosis resistance in T cell acute lymphoblastic leukemia (T-ALL) is...

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PMID: 30404791
DOI: 10.1084/jem.20180570

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