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Polycomb repressive complex 2 (PRC2) suppresses Eμ-myc lymphoma

28 Aug 2013

Abstract excerpt

Deregulation of polycomb group complexes polycomb repressive complex 1 (PRC1) and 2 (PRC2) is associated with human cancers. Although inactivating mutations in PRC2-encoding genes EZH2, EED, and SUZ12 are present in T-cell acute lymphoblastic leukemia and in myeloid malignancies, gain-of-function mutations in EZH2 are frequently observed in B-cell lymphoma, implying disease-dependent effects of individual...

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PMID: 23982173
DOI: 10.1182/blood-2013-02-484055

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