TOPOISOMERASE II INHIBITOR‐RELATED ACUTE MYELOID LEUKAEMIA

Abstract excerpt

In the late 1980s, we and colleagues described unique cases of treatment-related acute myeloid leukaemia (AML) in patients who had received intensive chemotherapy, including the epipodophyllotoxins, for acute lymphoblastic leukaemia (ALL) or solid tumours ( Ratain et al, 1987 ; DeVore et al, 1989 ; Pui et al, 1989 , 1990; Albain et al, 1990 ; Pedersen-Bjergaard et al, 1990 ; Prieto et al, 1990 ). A causative role...

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