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Article

HPA-axis multilocus genetic variation moderates associations between environmental stress and depressive symptoms among adolescents

5 Nov 2018

Abstract excerpt

Research suggests that genetic variants linked to hypothalamic-pituitary-adrenal (HPA)-axis functioning moderate the association between environmental stressors and depression, but examining gene-environment interactions with single polymorphisms limits power. The current study used a multilocus genetic profile score (MGPS) approach to measuring HPA-axis-related genetic variation and examined interactions with...

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PMID: 30394263
DOI: 10.1017/s0954579418000779

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