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Article

Hypothalamic-pituitary-adrenal Axis Multilocus Genetic Variation, Childhood Parenting and Adolescent Anxiety Symptoms: Evidence of Cumulative Polygenic Plasticity.

Journal of youth and adolescence - 1 Aug 2022

Cao Cong, Yang Shan, Sun Kexin, Gu Junlian

Abstract excerpt

Research suggests that genetic variants that regulate the hypothalamic-pituitary-adrenal (HPA) axis function moderate the association between parenting and anxiety symptoms, but these studies have primarily focused on (i) individual genes with very small and unreliable effect and (ii) the role of mothers as opposed to fathers. Using a multilocus genetic profile score approach, the current study is the first to...

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PMID: 35474403
DOI: 10.1007/s10964-022-01610-8

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