Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Variation in TMEM106B in chronic traumatic encephalopathy

31 Oct 2018

Abstract excerpt

The genetic basis of chronic traumatic encephalopathy (CTE) is poorly understood. Variation in transmembrane protein 106B (TMEM106B) has been associated with enhanced neuroinflammation during aging and with TDP-43-related neurodegenerative disease, and rs3173615, a missense coding SNP in TMEM106B, has been implicated as a functional variant in these processes. Neuroinflammation and TDP-43 pathology are prominent...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to S100 Proteins and Annexins
Share to Traumatic Brain Injury and Neurovascular Disturbances

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Traumatic Brain Injury Research

Source

Identifiers

PMID: 30390709
DOI: 10.1186/s40478-018-0619-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Variation in TMEM106B in chronic traumatic encephalopathyPMID 30390709Read ↗

Genetic variation in TMEM106B alters microglial activation and cytokine responses in chronic traumatic encephalopathy.Semantic proximity Read ↗

TMEM106B haplotypes have distinct gene expression patterns in aged brainSemantic proximity Read ↗

TMEM106B coding variant is protective and deletion detrimental in a mouse model of tauopathySemantic proximity Read ↗

Gene-Specific Effects on Brain Volume and Cognition of TMEM106B in Frontotemporal Lobar Degeneration.Semantic proximity Read ↗

TMEM106B risk variant is implicated in the pathologic presentation of Alzheimer disease.Semantic proximity Read ↗

TMEM106B a novel risk factor for frontotemporal lobar degeneration.Semantic proximity Read ↗

Association of APOE Genotypes and Chronic Traumatic Encephalopathy.Semantic proximity Read ↗

TMEM106B coding variant is protective and deletion detrimental in a mouse model of tauopathy.Semantic proximity Read ↗

Inflammation and neuronal gene expression changes differ in early versus late chronic traumatic encephalopathy brainSemantic proximity Read ↗

Gene specific effects on brain volume and cognition of<i>TMEM106B</i>in frontotemporal lobar degenerationSemantic proximity Read ↗

Inflammation and neuronal gene expression changes differ in early vs late chronic traumatic encephalopathy brainSemantic proximity Read ↗

The TMEM106B locus and TDP-43 pathology in older persons without FTLD.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.