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Article

Genetic variation in TMEM106B alters microglial activation and cytokine responses in chronic traumatic encephalopathy.

Acta neuropathologica - 20 Nov 2025

Hartman Shahar, Aytan Nurgul, Nicks Raymond, Hawkins Samantha, Cherry Jonathan, Alvarez Victor E, Meng Gaoyuan, Tripodis Yorghos, Martin Brett, Palmisano Joseph, Goldstein Lee E, Katz Douglas I, Dwyer Brigid, Daneshvar Daniel H, Crary John F, Alosco Michael, Xia Weiming, McKee Ann C, Mez Jesse, Stein Thor D

Abstract excerpt

Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease caused by repetitive head impacts (RHI). However, individuals with similar RHI exposure can show differing pathology, suggesting a role for genetic variation. A common Transmembrane Protein 106B (TMEM106B) risk variant is associated with greater CTE severity, though its mechanism remains unclear. To determine whether TMEM106B alters the...

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Identifiers

PMID: 41264095
DOI: 10.1007/s00401-025-02955-7
PMCID: PMC12634763

Genes

TMEM106B
TNF
TREM2
CD68

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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