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Article

Association of APOE Genotypes and Chronic Traumatic Encephalopathy.

JAMA neurology - 1 Aug 2022

Atherton Kathryn, Han Xudong, Chung Jaeyoon, Cherry Jonathan D, Baucom Zachary, Saltiel Nicole, Nair Evan, Abdolmohammadi Bobak, Uretsky Madeline, Khan Mohammed Muzamil, Shea Conor, Durape Shruti, Martin Brett M, Palmisano Joseph N, Farrell Kurt, Nowinski Christopher J, Alvarez Victor E, Dwyer Brigid, Daneshvar Daniel H, Katz Douglas I, Goldstein Lee E, Cantu Robert C, Kowall Neil W, Alosco Michael L, Huber Bertrand R, Tripodis Yorghos, Crary John F, Farrer Lindsay, Stern Robert A, Stein Thor D, McKee Ann C, Mez Jesse

Abstract excerpt

Importance: Repetitive head impact (RHI) exposure is the chief risk factor for chronic traumatic encephalopathy (CTE). However, the occurrence and severity of CTE varies widely among those with similar RHI exposure. Limited evidence suggests that the APOEε4 allele may confer risk for CTE, but previous studies were small with limited scope. Objective: To test the association between APOE genotype and CTE...

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Identifiers

PMID: 35759276
DOI: 10.1001/jamaneurol.2022.1634
PMCID: PMC9237800

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