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Article

Exosomal Wnt-induced dedifferentiation of colorectal cancer cells contributes to chemotherapy resistance

2 Nov 2018

Abstract excerpt

Cancer stem cells (CSCs) are inherently resistant to chemotherapy, and CSCs in chemotherapy-failed recurrent tumors are enriched; however, the cellular origin of chemotherapy-induced CSC enrichment remains unclear. Communication with stromal fibroblasts may induce cancer cell dedifferentiation into CSCs through secreted factors. We recently demonstrated that fibroblast-derived exosomes promote chemoresistance in...

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PMID: 30390075
DOI: 10.1038/s41388-018-0557-9

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