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Exosomes and their distinct integrins transfer the characteristics of oxaliplatin- and 5-FU-resistant behaviors in colorectal cancer cells

6 Feb 2025

Abstract excerpt

BACKGROUND: Exosomes are communication carriers and suitable biomarker candidates due to their cargoes with specific dynamic profiles. Integrins, as valuable prognostic markers in cancer, have importance in exosome-cell interaction. However, the role of exosome integrins in chemoresistant colorectal cancer remained unclear. METHODS: Oxaliplatin- and 5-FU-resistant cells (OXR and FUR) were established from human...

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PMID: 39915745
DOI: 10.1186/s10020-025-01110-y

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