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Article

Cancer associated fibroblasts-derived exosomes contribute to radioresistance through promoting colorectal cancer stem cells phenotype.

Experimental cell research - 15 Jun 2020

Liu Lei, Zhang Zhe, Zhou Lei, Hu Liya, Yin Cun, Qing Defeng, Huang Shanshan, Cai Xiuyu, Chen Yuan

Abstract excerpt

Radioresistance observed in patients with colorectal cancer (CRC) may be related to the presence of cancer stem cells (CSCs), but the underlying mechanism(s) remain unclear. Cancer-associated fibroblasts (CAFs) can regulate the stemness of cancer cells and tumor radiosensitivity. In addition, exosomes have been reported to modify treatment response by mediating cell-cell communication. In this study, we aimed to...

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Identifiers

PMID: 32169425
DOI: 10.1016/j.yexcr.2020.111956

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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