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Article

Epigenetic Targeting of Glioblastoma

16 Oct 2018

Abstract excerpt

Glioblastoma (GB) is one of the first tumors where the biological changes accompanying a single epigenetic modification, the methylation of the MGMT gene, were found to be of clinical relevance. The exploration of the epigenomic landscape of glioblastoma has allowed to identify patients carrying a diffuse hypermethylation at gene promoters and with better outcome (G-CIMP). Epigenetic and genetic data have led to...

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PMID: 30386738
DOI: 10.3389/fonc.2018.00448

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