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Article

Spontaneous Posterior Segment Vascular Disease Phenotype of a Mouse Model, rnv3 , Is Dependent on the Crb1 rd8 Allele

25 Oct 2018

Abstract excerpt

Purpose: To determine the molecular basis of lesion development in a murine model of spontaneous retinal vascularization, rnv3 (retinal vascularization 3, aka JR5558). Methods: Disease progression of rnv3 was examined in longitudinal studies by clinical evaluation, electroretinography (ERG) and light microscopy analyses. The chromosomal position for the recessive rnv3 mutation was determined by DNA pooling and...

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PMID: 30372741
DOI: 10.1167/iovs.18-25046

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